50 Best Games Like The Binding of Isaac You Should Try in 2022

Trying to find games like The Binding of Isaac? Try these 50 great games that are similar to The Binding of Isaac, but stand out in their own awesome ways. This is a comprehensive list of best games like The Binding of Isaac that have been tried, tested and recommended.

Best Games Like The Binding of Isaac

50 Best Games Like The Binding of Isaac You Should Try in 2022 The Binding of Isaac: Rebirth,bit Dungeon,HELLDIVERS,Plague Inc: Evolved,SYNTHETIK,Super Markup Man,Magic Duels,PixelJunk Shooter Ultimate,The Jackbox Party Pack 2,Shantae and the Pirate's Curse

1. The Binding of Isaac: Rebirth 

The Binding of Isaac: Rebirth is a remake of The Binding of Isaac.
The plot is based on a biblical story. Little Isaac and his mother live happily in a small house on the hill. And suddenly the mother heard a voice, which told her that her son is defiled by sins and must be saved. The voice asks the woman to remove all evil from Isaac to save him. There are 12 endings in the game.
By controlling Isaac or other of the six characters to choose from, the player must go through several levels of the...

2. bit Dungeon 

"It's a smartly and elegantly designed game that's not afraid to permakill you" --IndieGames.com"The distilled essence of every 8-bit action role-playing game ever. Love it." --Kotaku"Bit Dungeon brings together The Legend of Zelda’s top-down dungeon stomping, Diablo’s loot lust, and the unforgiving difficulty of roguelikes within a slick retro-style quest." --Mac|Life"It’s great fun, made even more entertaining by the retro visuals that bring to mind classics like The Legend of Zelda on NES."...

3. HELLDIVERS 

HELLDIVERS is a top-down shooter where you need to complete procedurally generated missions among the endless amount of enemies. While the game has a single-player mode, the gameplay is more suitable for a co-op playthrough. Unlike in many shooters, in HELLDIVERS you must avoid friendly fire as you can hurt your teammates. Another feature is that you can decide for yourself where to drop, which vehicles to use and choose the order of the objectives to complete.
The story is set on Super Earth where...

4. Plague Inc: Evolved 

Plague Inc: Evolved is a biological simulation/strategy game developed by Ndemic Creations.
In Plague Inc: Evolved the player controls a disease, that infects patient zero in a selected country. The player's goal is to infect and kill all the people perfecting the disease and adapting to different conditions.
Initially, more and more people get infected within a country, the disease goes through the borders, carried by animals, birds, insects, transits through blood or on public transport. Random...

5. SYNTHETIK 

SYNTHETIK has all the core components of a great rogue-lite - an insurmountable objective defended by relentless opponents and unforgiving bosses encased in ever-changing environments filled with a massive cache of weapons, items, perks and upgrades to discover. Join the fight alone or through seamless 2 player online co-op, but be careful; every fumble could mean the end. Can you defeat the Heart of Armageddon?With Synthetik we wanted to bring new depth and mechanics to the genre while leaving a...

6. Super Markup Man 

Learn HTML and CSS in the context of a 2D puzzle platformer! Super Markup Man teaches real web development practices without making you write any code. Simply carry the tags around the screen and watch your website render in real-time. Match your website with the preview to pass each level. The game includes: 100 levels/exercises HTML mode that covers basic tags like A, IMG, STRONG, and EM CSS mode for more advanced markup and styling Local co-op* Optional "bug" setting to keep you on your toes Free...

7. Magic Duels 

Magic Duels is a video game based on collectible card game Magic: The Gathering. It follows Magic: The Gathering – Duels of the Planeswalkers and its sequels. Unlike the predecessors, Magic Duels has a story mode that focuses on five original Planeswalkers. In general, the game features over 1300 earnable cards.
The gameplay repeats the one from the card game but is simplified. You participate in duels either with real players or AI opponents. Each player has a deck of cards consisting of lands...

8. PixelJunk Shooter Ultimate 

PixelJunk Shooter Ultimate edition includes PixelJunk Shooter and PixelJunk Shooter 2. Corresponding to the PixelJunk series, Ultimate covers the forth and the fifth parts of the franchise, consisting of 10 titles overall.
Remastered version
The refreshed version brings out the new mode of the same name: Ultimate, which changes design style of the game. The players can choose between Classic and Ultimate. It is also known that now progress can be transferred between the two parts of the original...

9. The Jackbox Party Pack 2 

The sequel to the party game phenomenon The Jackbox Party Pack, featuring FIVE fresh, rib-tickling party games! Games include:Fibbage 2 (2-8 players)The runaway hit bluffing game with over 500 brand-new questions, more than 2x the original! Plus new features, like the deFIBrillator!Earwax (3-8 players)The hear-larious sound-effects game that will leave you up to your ears in laughter!
Cow moo? Huge explosion? Or tiny fart? Which to choose?Bidiots (3-6 players)The absurd art auction game where you...

10. Shantae and the Pirate's Curse 

Shantae and the Pirate's Curse is an action platform game, the third installment in WayForward’s Shantae series.
Plot
The game follows the half-genie Shantae and takes place after an event of the Shantae: Risky’s Revenge. The main heroine abandons her genie powers and stars adjusting to the life of a regular human being. One day she comes across the previous game’s antagonist, a pirate named Risky Boots that tells her about evil and fearsome tyrant Pirate Master sealed long ago by genies...

11. Revenge of the Titans 

Revenge of the Titans is a sequel to Titan Attacks!
In the previous game, aliens who arrived from Titan on huge spacecraft to destroy us, were successfully stopped. But they flew again - to avenge the defeat. This time they prepared a full-scale landing on the surface of the planet. We have nothing left but to play the invisible commander of all the forces of mankind, to throw out the enemies and destroy them not only on our land, but also on their own planet Titan.
Like its predecessor, the game...

12. Strike Suit Zero 

Strike Suit Zero is a space flight combat game. The game was funded via Kickstarter and advertised itself as an attempt to revive space flight combat genre.
Plot and setting
The game takes place in the distant future. The main protagonist is a pilot for United Nations of Earth and must help his home planet in a war against united forces of space colonies.
Gameplay
The game consists of several missions. In each one of them, you participate in a massive space battle. The missions’ design intends...

13. SYNTHETIK: Arena 

SYNTHETIK: Arena is the Stand-Alone expansion to the Rogue-Lite Top-Down Shooter SYNTHETIK.With Synthetik we wanted to bring new depth and mechanics to the genre while leaving a lot of freedom for experimentation and different playstyles. It is inspired by the late 90’s Era of games when people put in all the Features they enjoyed without streamlining to the bare minimum.Stand your ground against relentless opponents in five unforgiving challenges. Master the uniquely deep and satisfying weapon...

14. Wishmaster 

Wishmaster is a game with an interesting and complex history of human desires and about the fact that not everything will go the way you wish. The game includes a part with Visual Novel, where you will learn about the world and the people themselves, and, certainly, about their dreams. The second part of the game is the game Match-3, where you will search for mysterious energy to fulfill all the dreams of mortal creatures. Also you will be able to track your progress in the gallery.

You start...

15. Mages of Mystralia 

In the kingdom of Mystralia, it takes more brains than brawn to succeed. You will face down giant, powerful creatures and navigate treacherous terrain. You will encounter puzzles that confound even the wisest of the old sages. And you must overcome obstacles put in place by people who do not want you to succeed.Your path will not be easy. In Mages of Mystralia, you play as Zia, a young girl who discovers that she has been born with an innate sense of magic. Unfortunately, magic has been banned, so...

16. The Legend of Bum-bo 

The Legend of Bum-bo is a puzzle based "deckbuilding roguelike" by Edmund McMillen (The Binding of isaac, Super Meat Boy) and James Interactive, where players collect hordes of items that can be modified, upgraded and comboed with others in many interesting ways. Play as one of many Bum-bo, each with its own unique abilities, as they smash, bash and splash their way through a variety of cardboard monstrosities, giant bosses and dark personal urges...
oh also its the prequel to The Binding...

17. Age of Conquest IV 

Age of Conquest is a turn-based grand strategy wargame. Command your armies in one of the many ancient and medieval countries including the Roman Empire, the Inca, France, Russia, Japan or the Chinese Dynasties. From Rome to Asian nations, you create your own warring experience. Wage colossal wars solo, against the AI, or take on your gaming friends in cross-platform multiplayer games. Form alliances and fight co-op style with the AI and other players for ultimate victory.Range of functionality is...

18. McOsu 

McOsu is an open-source practice client for the PC rhythm game osu!, developed from scratch by McKay42. While it is playable without an osu! installation or account, it does not support osu!'s online features and ranking system and lacks some gameplay elements from the main game such as health.
McOsu allows the player to individually override the difficulty values of the map he is playing (circle size, approach rate, overall difficulty and even game speed/song BPM). It also includes a multitude...

19. Geneforge 1 

Geneforge is an Indie fantasy role-playing game, the first game in the five-part Geneforge Saga. It features an enormous world, the ability to create your own army of lethal, totally obedient creatures, and a cunning enemy AI with foes who can go on patrols, stalk you, and run for help.
Geneforge has a huge and open storyline. You have the freedom to choose your own path and decide how the story will turn out. You can fight the evil overlord or you can join him. You can help the peasants or you can...

20. Aveyond 3-2: Gates of Night 

Chapter 2 in a four-part series! A vampire mage has acquired a magical relic with the power to enslave humanity. Are you brave enough to stop him? Take to the high seas and explore a massive world. Your goal: unlock the gate to Naylith, a mystical land filled with ancient knowledge, and the answer you need to defeat the vampire.Games that have been released in the series:Aveyond: Lord of Twilight (DOWNLOAD HERE) Aveyond: Gates of...

21. Fine Sweeper 

Players who just randomly clicked tiles open in past and never got the addictive rules have the option to learn the mechanics with a little tutorial slideshow. Seasoned players can test their abilities in the “Classic Mode” without extra-lives. Or set up your game independent from the campaign mode to either be a stroll in the park or a dash Through the Fire and Flames.The campaign offers levels increasing in difficulty and size of the playing field while staying true to the core mechanics. It...

22. StarDrive 

StarDrive sets a new benchmark for the ‘4X Space Strategy’ genre. Starting with a single planet and a small number of space-worthy vessels, you must venture forth into the galaxy, conquer new worlds, build new colonies and defend your very existence against those who would take what is yours. How you play is your decision. Use diplomacy or brute force. Trade, spy and research your way to galactic domination. Make friends, or create mortal enemies…The heart of StarDrive is its ship design...

23. Anima: Gate of memories 

Anima: Gate of Memories is a third person action RPG that tells the story of two beings bound by an unwilling pact, a legendary monster and a girl who lost her past...Forced to stay together, their existences will take an unexpected turn they discover that both have been involved in something sinister, a war in the shadows in which they will have an involuntary leading role.Gate of Memories features a unique Dual System that allows you to control two different characters and interchange them dynamically...

24. Super LOH 

Plunge into an incredible atmosphere of Super LoH (Layers of Horror) !Explore fascinating levels full of various monsters and and make enough money so you can buy gorgeous hat! And don't forget to save a beautiful lady! Or to buy one. You don't want to kill all the monsters alone, do you? Features: The boar +100 levels and more with every update! More than 20 types of monsters ready to kill you cruelly. Unique magic sticks available in the shop. Gorgeous hats! Amazing soundtrack by Classican...

25. Doodle Devil 

If You Love Doodle God…Embrace Your Dark Side with Doodle Devil!While Doodle God was busy creating the universe, Doodle Devil was also having some fun. The same addictive, puzzle game play that made Doodle God a hit is back but with an evil twist. Discover the seven deadly sins and watch as the world crumbles at your fingertips as you create thousands of dastardly deeds. Combine fire, earth, wind & air to create demons, beasts, zombies... and much more. Being bad has never been so much fun!CRITICS...

26. Take Thy Throne 

Take Thy Throne is an online sidescrolling tower defense game.

Currently we allow up to 6 players per match to enter a variety of gamemodes, with more gamemodes coming after release as free DLC.

The main gamemode consists of taking down towers and barricades to make your way towards the enemy team's King which lies in the Throne room of the enemy's castle. You can pick up to 4 classes currently to play with, with more being added after the game's release.

You can use a variety of strategies...

27. Ittle Dew 2 

Ittle and Tippsie crash onto yet another island filled with loot, puzzles and mysterious inhabitants! With the help of a magical map, they set out to steal eight pieces of a raft from increasingly improbable locations including beaches, prairies, an art exhibit and some dude's basement.
Ittle Dew 2 is a charming and humorous 3D Action Adventure game with a focus on exploration and combat. Tackle the game’s dungeons in any order and discover the many secrets of its expansive overworld. With...

28. A House of Many Doors 

Welcome to the House. You are not welcome.Explore the House, a parasite dimension that steals from other worlds, in a train that scuttles on mechanical legs. Uncover secrets. Open locked doors. Lead a crew of dysfunctional characters. Write procedurally-generated poems. Fight in turn-based combat. Explore a strange new setting, dripping with atmosphere, crusted with lore. Escape. Escape. Escape.You are an explorer, poet and spy, launching yourself into the unknown in search of adventure. Rig an election...

29. Porcunipine 

Porcunipine is a couch multiplayer about balding porcupines fighting courageously for survival using their very last pointy quills.The concept of the game is simple: You are a majestic and terribly violent porcunipine. You have one quill which you can shoot at your opponents. Once you shoot, you have to go and pick up that quill before you can shoot again. Your quill rebounds from walls and obstacles, and can kill you just as easily as it can kill your enemies. FIGHT to the death with sharp needles...

30. Monsters Ate My Birthday Cake 

As so many of these things do, it all begins on a magical island. In this case, Gogapoe Island, a place populated by both humans and monsters. What starts out as a mission to get back Niko's birthday cake becomes a quest for the fate of Gogapoe itself. But, ya know, cake is still super important, too!Oodles of friendly monsters will join Niko's quest and use their kooky powers to help him explore the island, solve puzzles, demolish obstacles, and just generally humiliate enemies. Hordes of evil monsters...

31. bit Dungeon+ 

You and your beloved friend were captured by demons...You wake up what seems like hours, maybe even days later trapped in a prison cell, and your friend is missing. You find a sword in your cell and vow revenge against the beasts who took your friend - the quest to find your friend one and destroy the demons begins!bit Dungeon combines the randomized loot of Diablo and fast action combat of Zelda. Explore randomized dungeons and hack and slash your way through dangerous bosses. The difficultly increases...

32. Zeroptian Invasion 

The Zeroptians have invaded the F1 planetary system. Eliminate the threat and proclaim yourself the winner of the galaxy!
Zeroptian Invasion is a miniature pixelated graphics and amazing chiptune type melodies inspired by classics such as Space Invaders, Galaga or Centipede.
👾CRT filter.
👾Challenging and classic gameplay.
👾Aesthetics pixel art in 1-bit with colors.
👾Levels totally unique and different from each other.
👾Incredible variety of enemies and memorable bosses.
👾OST on...

33. Z55Z 

Features:• pleasant pixel graphics and animation• 25 harsh levels• 6 key skills• Excellent musical accompaniment• full support for gamepadTake care of your nerves!...

34. Feral Fury 

Fast-paced twin stick shooter rogue-lite actionMay the soil we conquer nurture the holy seeds of the great bambooLong after humankind perished in the flames of the oil wars, the great panda empire is expanding throughout the galaxy as the new dominant power. With the old world in ashes and an endless need for bamboo, entire planets are turned into plantations, and the flames of war are lit once again.15 Procedurally-generated stages split into 5 chaptersTons of items including helmets, weapons, drones,...

35. Endless Road 

A Roguelike Card game, with a collection of equipment and combinations to defeat an enemy of different styles.Right click start your first step.Game FeaturesThree roles, each with different active skills.Dozens of equipment, jewelry makes your card stronger, and gemstones make you stronger.Randomly generated levels.Boss with different shapes.Different blessings after battle.Rich eventAll you have to do is walk.All you know is what's on the next road, please take this luck to the end.1. RoleThe game...

36. Modest Kind 

You wake up, imprisoned in decaying time vault. Place is crawling with Convicts gone mad, Memeplex creatures childishly wrecking everything and ancient artifacts of history lying around. Uncover the truth behind this place. Think you're smart enough to get out?GameplayTeam Vedanta presents Modest Kind, a Rogue-lite Initiation Adventure. Ever heard of Entropy, The Selfish Gene and Schrödinger's cat? This action-heavy, story-driven top-down dungeon crawler will put your knowledge to the test. Your...

37. Strange Things 

This is an indie game made with the aim of making a fun and random gameplay. Choose your weapons and start a randomly generated map, when you complete all the map, the game will finish.

What to expect:

-Various types of enemies with different movements and attacks.

-13 types of weapons, with different animations and different effects.

-Destructible scenario, only with some weapons.

-Original and retro soundtrack during gameplay.

How to play:

-WASD to move during gameplay

-Left mouse...

38. Combat Raccoon 

Combat Raccoon: in search of mysterious treasures.

Go to a dangerous expedition for treasures with combat raccoon. Help our brave pathfinder get the deserved reward! Pass 20 unforgettable levels and get to the chests with gold!

Our small searcher of adventures can:

- Run, jump and slide
- Climb the on walls and stairs
- Shoot, throw grenades, hit melee.
- Fly with the help of a jet pack.
- To swim.

You are wait death traps,dangerous enemies and exciting expedition. Forward for adventure!...

39. Sethian 

Sethian is a sci-fi puzzle game in which you master a fictitious language. An archaeologist in the distant future, you venture to the far-flung planet of Sethian, investigating the mysterious disappearance of the people there centuries ago. An abandoned computer may have the answers you seek, but it only operates in the lost native language. Master their language, unravel their mysteries, and challenge their philosophy.An Original LanguageUnlike in other games, Sethianese is a more earnest attempt...

40. Shadowlings 

Shadowlings - is a slaughter to heavy metal in decorations of Medieval Japan.After your Ninja clan helped The Great Shogan to seize power in the kingdom, he turned against you and destroyed your brothers.But you survived - and now vengeful Shadowling goes after Shogan, leaving blood trail behind him. Let the swords sing and ring, let the arrows and shurikens whistle, and let Shogan tremble in fear looking at the shadows darkening around him. Shadows of your brothers who he's treacherously killed,...

41. Woodboy 

In five days, the Woodboy will run out of magic and it will die.--------------------------------------------------------------------------------------------------Years have passed and the Lich has returned to the town. Years ago he was defeated by a hero but the doom has come again. The river is dry and the forests are full of danger. One little girl wants to save everyone in the town but she can't do it all alone...This is an adventure game that is played in short sesions of 5 min. Each time you...

42. Shadow Hunter 

Shadow Hunter is a casual deductive puzzle game with RPG elements. As a Shadow Hunter, you must use your senses to detect dangers and artifacts beneath the endless darkness that spreads throughout the land. Anti-light, the dimension and dimensional darkness from beyond the void gate, threatens to swallow us all. You must quest to find the Shadow Gate Fragments, to destroy the Anti-light menace.16 areas to explore.Deductive mini-games.Random events.Local high-score list.Great horror atmosphere.Turn-based....

43. Puzzle Chambers 

You wake up in an unknown place and soon run into a few more people who have also been abducted. You quickly discover three things: -Everyone here has supernatural abilities-The only way to move through this cryptic place is by solving puzzles-And your hosts are either aliens, monsters from another dimension, or severely messed up human beings Features:-Unique, easy to understand and difficult to solve puzzles-At least one or two plot twists-A few disturbingly easy-going and few disturbingly simple-minded...

44. Erinye Demo 

Erinye is a PC adventure game with some RPG tints, where you explore a 2D world, full of dungeons, castles, mazes, towns, secrtets, puzzles, treasures and different enemies to fight, swinging weapons, magic or other trinkets you will find on your way.StoryThe story begins when our heroine, Erin, arrives to the town of Azuliris, following the trail of a mysterious witch who, rumors say, carries a very valuable treasure with her.Things get difficult when in Azuliris, Erin meets the ShyGirls, a group...

45. Déjà Vu: MacVenture Series 

You wake up in a bathroom stall in a seedy Chicago bar with no idea of how you got here or, for that matter, who you are. You’ve dealt with the effects of benders before and this ain’t one of those. As you shake your head (hoping some memories might shake loose), you notice a ’38 hanging on the door. You check the chamber – six shells – three of them empty. That can’t be good. You gather your trench coat, stumble up the stairs and find some stiff slumped over a desk. There’s three bullets...

46. Conga Master 

The dance floor fills, the line gets longer… come on down, it's time to conga! Shake your virtual hips to the ridiculously fun arcade action of Conga Master as everyone fights to make the longest conga line possible. No rhythm required – anyone can conga!Playing Conga Master couldn't be easier: guide your dancer across the floor, dancing round people to add them to your line as you go. Longer congas let you add people faster, but watch out for pigs stinking up your line! Play solo or, even better,...

47. RunningDead 

Running Dead is a puzzle & shot game. You will control zombies. Chase and bite the human.
Your little zombies will bounce back in the crowd, you can strike all of them by one shot.
But it's not easy for you, because there are so many people, if you keep them too close, you'll be killed.

Fortunately, you have Dr.Dead.
You can buy and active some powerful skills: some specific zombies or Infectious virus, or more powerful items.

Now we have:
- 6 different zombies
- 13 zombie skins from...

48. Just A Dream 

PLEASE NOTE that all screenshots / the trailer are not up to date with the current version and will be updated prior releaseJust a Dream is a fast paced top down action game. You enter a world filled with your worst nightmares and must escape. As you fight across your dream from level to level, you encounter the very things that you dread every night. Pick up unique weapons and use magical abilities that allow you to traverse the lands of nightmares and monsters to conquer Anxiety, Fear, and Despair...

49. Radio Commander 

In Radio Commander you are playing as an American military commander serving in US Army during the Vietnam War. You will be carrying heavy burden as your mission is to coordinate military operations taking place between 1965 and 1967. But this is not just another RTS, in which you are an invisible being hovering over the battlefield. In Radio Commander situation reports are given to you in form of dramatic radio statements sent by troops fighting on the ground. And your only accessory is a strategic...

50. Disintegration 

Disintegration is a new sci-fi first-person shooter set in the near future on Earth where the only hope for human survival is through Integration, a process developed to preserve human brains in robotic armatures. You play as Romer Shoal, a former Gravcycle pilot in command of a small Integrated resistance still grasping onto fading memories of their human selves. With the domineering Rayonne forces set on eliminating the final remnants of human society, it’s up to Romer and his crew of Outlaws...

What is the plot of The Binding of Isaac?